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Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein

BACKGROUND: The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and pathogenesis of prion d...

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Detalles Bibliográficos
Autores principales:	Lawson, Victoria A., Lumicisi, Brooke, Welton, Jeremy, Machalek, Dorothy, Gouramanis, Katrina, Klemm, Helen M., Stewart, James D., Masters, Colin L., Hoke, David E., Collins, Steven J., Hill, Andrew F.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925953/ https://www.ncbi.nlm.nih.gov/pubmed/20808809 http://dx.doi.org/10.1371/journal.pone.0012351

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