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Biotin Synthesis Begins by Hijacking the Fatty Acid Synthetic Pathway

Although biotin is an essential enzyme cofactor found in all three domains of life, our knowledge of its biosynthesis remains fragmentary. Most of the carbon atoms of biotin are derived from pimelic acid, a seven carbon dicarboxylic acid, but the mechanism whereby Escherichia coli assembles this int...

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Detalles Bibliográficos
Autores principales: Lin, Steven, Hanson, Ryan E., Cronan, John E.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925990/
https://www.ncbi.nlm.nih.gov/pubmed/20693992
http://dx.doi.org/10.1038/nchembio.420