Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR,...

Descripción completa

Detalles Bibliográficos
Autores principales: Díaz-Moreno, Irene, Hollingworth, David, Kelly, Geoff, Martin, Stephen, García-Mayoral, MaríaFlor, Briata, Paola, Gherzi, Roberto, Ramos, Andres
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926597/
https://www.ncbi.nlm.nih.gov/pubmed/20385598
http://dx.doi.org/10.1093/nar/gkq216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926597/
https://www.ncbi.nlm.nih.gov/pubmed/20385598
http://dx.doi.org/10.1093/nar/gkq216

Ejemplares similares