Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities

In response to replication-blocking DNA lesions, proliferating cell nuclear antigen (PCNA) can be conjugated with a single ubiquitin (Ub) or Lys63-linked Ub chains at the Lys164 residue, leading to two modes of DNA damage tolerance (DDT), namely translesion synthesis (TLS) and error-free DDT, respec...

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Detalles Bibliográficos
Autores principales: Pastushok, Landon, Hanna, Michelle, Xiao, Wei
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926605/
https://www.ncbi.nlm.nih.gov/pubmed/20385585
http://dx.doi.org/10.1093/nar/gkq239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926605/
https://www.ncbi.nlm.nih.gov/pubmed/20385585
http://dx.doi.org/10.1093/nar/gkq239

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