Cargando…

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors

Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated. Here, we employed a high-throughput in vivo Screening PLatform for In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Culler, Stephanie J., Hoff, Kevin G., Voelker, Rodger B., Berglund, J. Andrew, Smolke, Christina D.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926609/ https://www.ncbi.nlm.nih.gov/pubmed/20385591 http://dx.doi.org/10.1093/nar/gkq248

Ejemplares similares

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
por: Goers, Emily S., et al.
Publicado: (2010)

Identification of motifs that function in the splicing of non-canonical introns
por: Murray, Jill I, et al.
Publicado: (2008)

An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM
por: Pastor, Tibor, et al.
Publicado: (2009)

Overlapping splicing regulatory motifs—combinatorial effects on splicing
por: Goren, Amir, et al.
Publicado: (2010)

Frequent Gain and Loss of Intronic Splicing Regulatory Elements during the Evolution of Vertebrates
por: Voelker, Rodger B., et al.
Publicado: (2012)

Global control of aberrant splice-site activation by auxiliary splicing sequences: evidence for a gradient in exon and intron definition
por: Královičová, Jana, et al.
Publicado: (2007)

Self-splicing of a group IIC intron: 5′ exon recognition and alternative 5′ splicing events implicate the stem–loop motif of a transcriptional terminator
por: Toor, Navtej, et al.
Publicado: (2006)

Isolation and characterization of post-splicing lariat–intron complexes
por: Yoshimoto, Rei, et al.
Publicado: (2009)

Splicing-coupled 3′ end formation requires a terminal splice acceptor site, but not intron excision
por: Davidson, Lee, et al.
Publicado: (2013)

Alternative splicing and bioinformatic analysis of human U12-type introns
por: Chang, Wen-Cheng, et al.
Publicado: (2007)

Complex splicing control of the human Thrombopoietin gene by intronic G runs
por: Marcucci, Roberto, et al.
Publicado: (2007)

Antagonistic factors control the unproductive splicing of SC35 terminal intron
por: Dreumont, Natacha, et al.
Publicado: (2010)

Splicing of many human genes involves sites embedded within introns
por: Kelly, Steven, et al.
Publicado: (2015)

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing
por: Kong, Ka-Yiu Edwin, et al.
Publicado: (2014)

Trans-splicing of the Ll.LtrB group II intron in Lactococcus lactis
por: Belhocine, Kamila, et al.
Publicado: (2007)

Extensive mis-splicing of a bi-partite plant mitochondrial group II intron
por: Elina, Helen, et al.
Publicado: (2010)

Introns regulate the production of ribosomal proteins by modulating splicing of duplicated ribosomal protein genes
por: Petibon, Cyrielle, et al.
Publicado: (2016)

Splicing of internal large exons is defined by novel cis-acting sequence elements
por: Bolisetty, Mohan T., et al.
Publicado: (2012)

Blocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells
por: Bruun, Gitte H, et al.
Publicado: (2018)

Alternate processing of Flt1 transcripts is directed by conserved cis-elements within an intronic region of FLT1 that reciprocally regulates splicing and polyadenylation
por: Thomas, Christie P., et al.
Publicado: (2010)

A conserved 3′ extension in unusual group II introns is important for efficient second-step splicing
por: Stabell, Fredrik B., et al.
Publicado: (2009)

Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position
por: Shen, Manli, et al.
Publicado: (2012)

Structural accommodations accompanying splicing of a group II intron RNP
por: Dong, Xiaolong, et al.
Publicado: (2018)

Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12
por: Haque, Ariful, et al.
Publicado: (2010)

O-GlcNAc regulates gene expression by controlling detained intron splicing
por: Tan, Zhi-Wei, et al.
Publicado: (2020)

Modeling splicing outcome by combining 5′ss strength and splicing regulatory elements
por: Müller, Lisa, et al.
Publicado: (2022)

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns
por: Doktor, Thomas Koed, et al.
Publicado: (2017)

SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer
por: Buratti, Emanuele, et al.
Publicado: (2007)

Splicing of the Sinorhizobium meliloti RmInt1 group II intron provides evidence of retroelement behavior
por: Chillón, Isabel, et al.
Publicado: (2011)

Key features of the two-intron Saccharomyces cerevisiae gene SUS1 contribute to its alternative splicing
por: Hossain, Munshi Azad, et al.
Publicado: (2011)

Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani
por: McNeil, Bonnie A., et al.
Publicado: (2014)

RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts
por: Sorber, Katherine, et al.
Publicado: (2011)

Group II intron in Bacillus cereus has an unusual 3′ extension and splices 56 nucleotides downstream of the predicted site
por: Stabell, Fredrik B., et al.
Publicado: (2007)

A trans-splicing group I intron and tRNA-hyperediting in the mitochondrial genome of the lycophyte Isoetes engelmannii
por: Grewe, Felix, et al.
Publicado: (2009)

A G-tract element in apoptotic agents-induced alternative splicing
por: Hai, Yan, et al.
Publicado: (2008)

Genomic HEXploring allows landscaping of novel potential splicing regulatory elements
por: Erkelenz, Steffen, et al.
Publicado: (2014)

Succession of splicing regulatory elements determines cryptic 5΄ss functionality
por: Brillen, Anna-Lena, et al.
Publicado: (2017)

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing
por: Saha, Kaushik, et al.
Publicado: (2020)

Tetrahymena thermophila and Candida albicans Group I intron-derived ribozymes can catalyze the trans-excision-splicing reaction
por: Dotson, P. Patrick, et al.
Publicado: (2008)

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing
por: Penn, Andrew C., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5a805c80s240cn2el0cllhl02b