A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

Interactions between SH2 domains and phosphotyrosine sites regulate tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging due to the high homology among the 120 human SH2 domains. Using an improved phage-display selection system, we generated a small antibod...

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Detalles Bibliográficos
Autores principales: Wojcik, John, Hantschel, Oliver, Grebien, Florian, Kaupe, Ines, Bennett, Keiryn L., Barkinge, John, Jones, Richard B., Koide, Akiko, Superti-Furga, Giulio, Koide, Shohei
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926940/
https://www.ncbi.nlm.nih.gov/pubmed/20357770
http://dx.doi.org/10.1038/nsmb.1793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926940/
https://www.ncbi.nlm.nih.gov/pubmed/20357770
http://dx.doi.org/10.1038/nsmb.1793

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