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A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
Interactions between SH2 domains and phosphotyrosine sites regulate tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging due to the high homology among the 120 human SH2 domains. Using an improved phage-display selection system, we generated a small antibod...
Autores principales: | Wojcik, John, Hantschel, Oliver, Grebien, Florian, Kaupe, Ines, Bennett, Keiryn L., Barkinge, John, Jones, Richard B., Koide, Akiko, Superti-Furga, Giulio, Koide, Shohei |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926940/ https://www.ncbi.nlm.nih.gov/pubmed/20357770 http://dx.doi.org/10.1038/nsmb.1793 |
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