Cargando…

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

Interactions between SH2 domains and phosphotyrosine sites regulate tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging due to the high homology among the 120 human SH2 domains. Using an improved phage-display selection system, we generated a small antibod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wojcik, John, Hantschel, Oliver, Grebien, Florian, Kaupe, Ines, Bennett, Keiryn L., Barkinge, John, Jones, Richard B., Koide, Akiko, Superti-Furga, Giulio, Koide, Shohei
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926940/ https://www.ncbi.nlm.nih.gov/pubmed/20357770 http://dx.doi.org/10.1038/nsmb.1793

Ejemplares similares

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
por: Grebien, Florian, et al.
Publicado: (2011)

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies
por: Kükenshöner, Tim, et al.
Publicado: (2017)

Proof of dual-topology architecture of Fluc F(-) channels with monobody blockers
por: Stockbridge, Randy B., et al.
Publicado: (2014)

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
por: La Sala, Grégory, et al.
Publicado: (2020)

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
por: Filippakopoulos, Panagis, et al.
Publicado: (2008)

Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable”
por: Hantschel, Oliver, et al.
Publicado: (2011)

Facile target validation in an animal model with intracellularly expressed monobodies
por: Gupta, Ankit, et al.
Publicado: (2018)

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis
por: Mian, Afsar A., et al.
Publicado: (2019)

Monobodies and other synthetic binding proteins for expanding protein science
por: Sha, Fern, et al.
Publicado: (2017)

Monobodies as tool biologics for accelerating target validation and druggable site discovery
por: Akkapeddi, Padma, et al.
Publicado: (2021)

Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation
por: Sha, Fern, et al.
Publicado: (2023)

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
por: Wallon, Lauren, et al.
Publicado: (2022)

Directed Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase
por: Huang, Renhua, et al.
Publicado: (2016)

Initial characterization of the human central proteome
por: Burkard, Thomas R, et al.
Publicado: (2011)

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors
por: Akkapeddi, Padma, et al.
Publicado: (2023)

Monobodies as possible next-generation protein therapeutics – a perspective
por: Oliver, Hantschel
Publicado: (2017)

Cell biology: A key driver of therapeutic innovation
por: Hantschel, Oliver, et al.
Publicado: (2012)

The SH2 Domain Regulates c-Abl Kinase Activation by a Cyclin-Like Mechanism and Remodulation of the Hinge Motion
por: Dölker, Nicole, et al.
Publicado: (2014)

Affinity Purification Strategies for Proteomic Analysis of Transcription Factor Complexes
por: Giambruno, Roberto, et al.
Publicado: (2013)

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins
por: Schmit, Nadine Eliane, et al.
Publicado: (2019)

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
por: Soulat, Didier, et al.
Publicado: (2008)

FN3-based monobodies selective for the receptor binding domain of the SARS-CoV-2 spike protein
por: Miller, Christina J., et al.
Publicado: (2021)

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
por: Winger, Jonathan A, et al.
Publicado: (2009)

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
por: Albert, C., et al.
Publicado: (2022)

Mig6 Is a Sensor of EGF Receptor Inactivation that Directly Activates c-Abl to Induce Apoptosis during Epithelial Homeostasis
por: Hopkins, Sarah, et al.
Publicado: (2012)

Synthesis of the l- and d-SH2 domain of the leukaemia oncogene Bcr-Abl
por: Schmidt, Nina, et al.
Publicado: (2022)

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
por: Reckel, Sina, et al.
Publicado: (2017)

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly
por: Hatzopoulos, Georgios N., et al.
Publicado: (2021)

Among Antibody-Like Molecules, Monobodies, Able to Interact with Nucleocapsid Protein of SARS-CoV Virus, There Are Monobodies with High Affinity to Nucleocapsid Protein of SARS-CoV-2 Virus
por: Khramtsov, Y. V., et al.
Publicado: (2022)

A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL
por: Rix, Uwe, et al.
Publicado: (2013)

Experimental characterization of the human non-sequence-specific nucleic acid interactome
por: Dürnberger, Gerhard, et al.
Publicado: (2013)

Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern
por: Kondo, Taishi, et al.
Publicado: (2022)

CD14 is a coreceptor of Toll-like receptors 7 and 9
por: Baumann, Christoph L., et al.
Publicado: (2010)

Mutational and biophysical robustness in a prestabilized monobody
por: Chandler, Peter G., et al.
Publicado: (2021)

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production
por: Eberle, Carol-Ann, et al.
Publicado: (2014)

Proteome-wide small molecule and metabolite interaction mapping
por: Huber, Kilian V. M., et al.
Publicado: (2015)

Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
por: Müller, André C., et al.
Publicado: (2016)

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody
por: Rizk, Shahir S., et al.
Publicado: (2017)

Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain
por: Chandler, Peter G., et al.
Publicado: (2020)

Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT
por: Diver, Melinda M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rhl7bbpuj8ntg8s7ald69av7p1