Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2(ΔGF122)) and structural roles of F122 in target recognition

BACKGROUND: ALG-2 (a gene product of PDCD6) belongs to the penta-EF-hand (PEF) protein family and Ca(2+)-dependently interacts with various intracellular proteins including mammalian Alix, an adaptor protein in the ESCRT system. Our previous X-ray crystal structural analyses revealed that binding of...

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Detalles Bibliográficos
Autores principales: Inuzuka, Tatsutoshi, Suzuki, Hironori, Kawasaki, Masato, Shibata, Hideki, Wakatsuki, Soichi, Maki, Masatoshi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927601/
https://www.ncbi.nlm.nih.gov/pubmed/20691033
http://dx.doi.org/10.1186/1472-6807-10-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927601/
https://www.ncbi.nlm.nih.gov/pubmed/20691033
http://dx.doi.org/10.1186/1472-6807-10-25

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