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Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2(ΔGF122)) and structural roles of F122 in target recognition
BACKGROUND: ALG-2 (a gene product of PDCD6) belongs to the penta-EF-hand (PEF) protein family and Ca(2+)-dependently interacts with various intracellular proteins including mammalian Alix, an adaptor protein in the ESCRT system. Our previous X-ray crystal structural analyses revealed that binding of...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927601/ https://www.ncbi.nlm.nih.gov/pubmed/20691033 http://dx.doi.org/10.1186/1472-6807-10-25 |