Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture

OBJECTIVE: Vascular endothelial growth factor (VEGF) contributes to diabetic retinopathy, but control of its expression is not well understood. Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP)...

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Detalles Bibliográficos
Autores principales: Schrufer, Tabitha L., Antonetti, David A., Sonenberg, Nahum, Kimball, Scot R., Gardner, Thomas W., Jefferson, Leonard S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927931/
https://www.ncbi.nlm.nih.gov/pubmed/20547975
http://dx.doi.org/10.2337/db10-0148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927931/
https://www.ncbi.nlm.nih.gov/pubmed/20547975
http://dx.doi.org/10.2337/db10-0148

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