A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA

Proliferating cell nuclear antigen (PCNA) acts as a scaffold, coordinator, and stimulator of numerous processes required for faithful transmission of genetic information. Maintaining PCNA levels above a critical threshold is essential, but little is known about PCNA protein turnover. We now show tha...

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Detalles Bibliográficos
Autores principales: Groehler, Angela L., Lannigan, Deborah A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928013/
https://www.ncbi.nlm.nih.gov/pubmed/20733054
http://dx.doi.org/10.1083/jcb.201002124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928013/
https://www.ncbi.nlm.nih.gov/pubmed/20733054
http://dx.doi.org/10.1083/jcb.201002124

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