Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in o...

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Detalles Bibliográficos
Autores principales: Biarnés, Xevi, Marchiori, Alessandro, Giorgetti, Alejandro, Lanzara, Carmela, Gasparini, Paolo, Carloni, Paolo, Born, Stephan, Brockhoff, Anne, Behrens, Maik, Meyerhof, Wolfgang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928277/
https://www.ncbi.nlm.nih.gov/pubmed/20811630
http://dx.doi.org/10.1371/journal.pone.0012394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928277/
https://www.ncbi.nlm.nih.gov/pubmed/20811630
http://dx.doi.org/10.1371/journal.pone.0012394

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