Cargando…

Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biarnés, Xevi, Marchiori, Alessandro, Giorgetti, Alejandro, Lanzara, Carmela, Gasparini, Paolo, Carloni, Paolo, Born, Stephan, Brockhoff, Anne, Behrens, Maik, Meyerhof, Wolfgang
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928277/ https://www.ncbi.nlm.nih.gov/pubmed/20811630 http://dx.doi.org/10.1371/journal.pone.0012394

Ejemplares similares

Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding
por: Marchiori, Alessandro, et al.
Publicado: (2013)

Dual binding mode of “bitter sugars” to their human bitter taste receptor target
por: Fierro, Fabrizio, et al.
Publicado: (2019)

Immunohistochemical Detection of TAS2R38 Protein in Human Taste Cells
por: Behrens, Maik, et al.
Publicado: (2012)

A Subset of Mouse Colonic Goblet Cells Expresses the Bitter Taste Receptor Tas2r131
por: Prandi, Simone, et al.
Publicado: (2013)

Bitter Odorants and Odorous Bitters: Toxicity and Human TAS2R Targets
por: Margulis, Eitan, et al.
Publicado: (2023)

Bitter Peptides YFYPEL, VAPFPEVF, and YQEPVLGPVRGPFPIIV, Released during Gastric Digestion of Casein, Stimulate Mechanisms of Gastric Acid Secretion via Bitter Taste Receptors TAS2R16 and TAS2R38
por: Richter, Phil, et al.
Publicado: (2022)

TAS2R38 bitter taste genotype is associated with complementary feeding behavior in infants
por: Cont, Gabriele, et al.
Publicado: (2019)

Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
por: Risso, Davide S., et al.
Publicado: (2016)

TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
por: Montrasio, Giulia, et al.
Publicado: (2015)

Corrigendum: Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
por: Risso, Davide S., et al.
Publicado: (2016)

TAS2R38 bitter taste receptor and attainment of exceptional longevity
por: Melis, Melania, et al.
Publicado: (2019)

Functional divergence of the bitter receptor TAS2R38 in Sulawesi macaques
por: Widayati, Kanthi Arum, et al.
Publicado: (2019)

Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38
por: Mennella, Julie A, et al.
Publicado: (2010)

Genetic Variation in the TAS2R38 Bitter Taste Receptor and Smoking Behaviors
por: Risso, Davide S., et al.
Publicado: (2016)

Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors
por: Di Pizio, Antonella, et al.
Publicado: (2018)

A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs
por: Sandau, Michelle M, et al.
Publicado: (2015)

Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
por: Boxer, Emma E., et al.
Publicado: (2015)

At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors
por: Behrens, Maik, et al.
Publicado: (2020)

Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans
por: Choi, Jeong-Hwa, et al.
Publicado: (2016)

Variation in the TAS2R38 Bitterness Receptor Gene Was Associated with Food Consumption and Obesity Risk in Koreans
por: Choi, Jeong-Hwa
Publicado: (2019)

Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients
por: Risso, D., et al.
Publicado: (2022)

From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds
por: Cheled-Shoval, Shira, et al.
Publicado: (2017)

Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception
por: Roudnitzky, Natacha, et al.
Publicado: (2015)

Expanding the role of bitter taste receptor in extra oral tissues: TAS2R38 is expressed in human adipocytes
por: Cancello, Raffaella, et al.
Publicado: (2020)

The influence of TAS2R38 bitter taste gene polymorphisms on obesity risk in three racially diverse groups
por: Chupeerach, Chaowanee, et al.
Publicado: (2021)

Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists
por: Grassin-Delyle, Stanislas, et al.
Publicado: (2019)

Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39
por: Morini, Gabriella, et al.
Publicado: (2021)

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans
por: Choi, Jeong-Hwa, et al.
Publicado: (2017)

TAS2R38 Bitter Taste Receptor Expression in Chronic Rhinosinusitis with Nasal Polyps: New Data on Polypoid Tissue
por: Jeruzal-Świątecka, Joanna, et al.
Publicado: (2022)

Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case
por: Di Pizio, Antonella, et al.
Publicado: (2017)

Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin
por: Greene, Tiffani A., et al.
Publicado: (2011)

Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells
por: Wölfle, Ute, et al.
Publicado: (2016)

BitterMatch: recommendation systems for matching molecules with bitter taste receptors
por: Margulis, Eitan, et al.
Publicado: (2022)

TAS2R38 Predisposition to Bitter Taste Associated with Differential Changes in Vegetable Intake in Response to a Community-Based Dietary Intervention
por: Calancie, Larissa, et al.
Publicado: (2018)

Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans
por: Benish,, et al.
Publicado: (2023)

Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition
por: Tran, Hoai T. T., et al.
Publicado: (2021)

6-Methoxyflavanones as Bitter Taste Receptor Blockers for hTAS2R39
por: Roland, Wibke S. U., et al.
Publicado: (2014)

Global population genetics and diversity in the TAS2R bitter taste receptor family
por: Wooding, Stephen P., et al.
Publicado: (2022)

Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)
por: Tan, Shi Min, et al.
Publicado: (2022)

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
por: Tsutsui, Kei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sl39f4m3dcfsq51bl78klgbfo5