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Chromosome Tips Damaged in Anaphase Inhibit Cytokinesis
Genome maintenance is ensured by a variety of biochemical sensors and pathways that repair accumulated damage. During mitosis, the mechanisms that sense and resolve DNA damage remain elusive. Studies have demonstrated that damage accumulated on lagging chromosomes can activate the spindle assembly c...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928297/ https://www.ncbi.nlm.nih.gov/pubmed/20811641 http://dx.doi.org/10.1371/journal.pone.0012398 |