Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

Sodium pyruvate can increase mitochondrial biogenesis in C2C12 myoblasts in a peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α)-independent manner. The present study examined the effect of 72-h treatment with sodium pyruvate (5–50 mM) or sodium chloride (50 mM) as an osmotic contro...

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Detalles Bibliográficos
Autores principales: Philp, Andrew, Perez-Schindler, Joaquin, Green, Charlotte, Hamilton, D. Lee, Baar, Keith
Formato: Texto
Lenguaje:English
Publicado: American Physiological Society 2010
Materias:
Cellular and Mitochondrial Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928631/
https://www.ncbi.nlm.nih.gov/pubmed/20410436
http://dx.doi.org/10.1152/ajpcell.00438.2009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928631/
https://www.ncbi.nlm.nih.gov/pubmed/20410436
http://dx.doi.org/10.1152/ajpcell.00438.2009

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