Trastuzumab Mediated T-Cell Response against HER-2/Neu Overexpressing Esophageal Adenocarcinoma Depends on Intact Antigen Processing Machinery

BACKGROUND: Esophageal adenocarcinoma (EAC) is a highly aggressive disease with poor prognosis, which frequently exhibits HER-2 gene amplification. Trastuzumab, the humanized antibody against HER-2, has potent growth inhibitory effects on HER-2 overexpressing cancers. One effect of trastuzumab is th...

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Detalles Bibliográficos
Autores principales: Milano, Francesca, Guarriera, Mirta, Rygiel, Agnieszka M., Krishnadath, Kausilia K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928738/
https://www.ncbi.nlm.nih.gov/pubmed/20865050
http://dx.doi.org/10.1371/journal.pone.0012424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928738/
https://www.ncbi.nlm.nih.gov/pubmed/20865050
http://dx.doi.org/10.1371/journal.pone.0012424

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