Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3

Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway. It contains multiple ubiquitin binding sites through which it anchors polyubiquitin chains of different link...

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Detalles Bibliográficos
Autores principales: Nicastro, Giuseppe, Todi, Sokol V., Karaca, Ezgi, Bonvin, Alexandre M. J. J., Paulson, Henry L., Pastore, Annalisa
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928749/
https://www.ncbi.nlm.nih.gov/pubmed/20865150
http://dx.doi.org/10.1371/journal.pone.0012430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928749/
https://www.ncbi.nlm.nih.gov/pubmed/20865150
http://dx.doi.org/10.1371/journal.pone.0012430

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