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Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3
Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway. It contains multiple ubiquitin binding sites through which it anchors polyubiquitin chains of different link...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928749/ https://www.ncbi.nlm.nih.gov/pubmed/20865150 http://dx.doi.org/10.1371/journal.pone.0012430 |