A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Riddick, Nadeene E., Hermann, Emilia A., Loftin, Lamorris M., Elliott, Sarah T., Wey, Winston C., Cervasi, Barbara, Taaffe, Jessica, Engram, Jessica C., Li, Bing, Else, James G., Li, Yingying, Hahn, Beatrice H., Derdeyn, Cynthia A., Sodora, Donald L., Apetrei, Cristian, Paiardini, Mirko, Silvestri, Guido, Collman, Ronald G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928783/
https://www.ncbi.nlm.nih.gov/pubmed/20865163
http://dx.doi.org/10.1371/journal.ppat.1001064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928783/
https://www.ncbi.nlm.nih.gov/pubmed/20865163
http://dx.doi.org/10.1371/journal.ppat.1001064

Ejemplares similares