Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. Here we show that a similar form of functional antagonism is produced by sustained inactivation of monoacylglycerol lipase (MAGL), the princi...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlosburg, Joel E., Blankman, Jacqueline L., Long, Jonathan Z., Nomura, Daniel K., Pan, Bin, Kinsey, Steven G., Nguyen, Peter T., Ramesh, Divya, Booker, Lamont, Burston, James J., Thomas, Elizabeth A., Selley, Dana E., Sim-Selley, Laura J., Liu, Qingsong, Lichtman, Aron H., Cravatt, Benjamin F.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928870/
https://www.ncbi.nlm.nih.gov/pubmed/20729846
http://dx.doi.org/10.1038/nn.2616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928870/
https://www.ncbi.nlm.nih.gov/pubmed/20729846
http://dx.doi.org/10.1038/nn.2616

Ejemplares similares