A novel pathway regulates memory and plasticity via SIRT1 and miR-134

The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative lifespan in budding yeast and was subsequently shown to modulate longevity in worms and flies1,2. Its mammalian homologue, SIRT1, appears to have evolved complex systemic roles in cardiac function, DNA repair, a...

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Detalles Bibliográficos
Autores principales: Gao, Jun, Wang, Wen-Yuan, Mao, Ying-Wei, Gräff, Johannes, Guan, Ji-Song, Pan, Ling, Mak, Gloria, Kim, Dohoon, Su, Susan C., Tsai, Li-Huei
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928875/
https://www.ncbi.nlm.nih.gov/pubmed/20622856
http://dx.doi.org/10.1038/nature09271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928875/
https://www.ncbi.nlm.nih.gov/pubmed/20622856
http://dx.doi.org/10.1038/nature09271

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