Ral activation promotes melanomagenesis

Up to one third of human melanomas are characterized by an oncogenic mutation in the gene encoding the small GTPase NRAS. Ras proteins activate three primary classes of effectors: Rafs, PI3Ks, and RalGEFs. In melanomas lacking NRAS mutations, the first two effectors can still be activated vis-à-vis...

Descripción completa

Detalles Bibliográficos
Autores principales: Zipfel, Patty A., Brady, Donita C., Kashatus, David F., Ancrile, Brooke D., Tyler, Douglas S., Counter, Christopher M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928877/
https://www.ncbi.nlm.nih.gov/pubmed/20562921
http://dx.doi.org/10.1038/onc.2010.224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928877/
https://www.ncbi.nlm.nih.gov/pubmed/20562921
http://dx.doi.org/10.1038/onc.2010.224

Ejemplares similares