Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

We show here that the voltage-gated K(+) channel Kv12.2 is a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 significantly reduced firing threshold in these neurons. Kv12.2(−/−) mice displayed signs of persistent neuronal hyperexc...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaofei, Bertaso, Federica, Yoo, Jong W., Baumgärtel, Karsten, Clancy, Sinead M., Lee, Van, Cienfuegos, Cynthia, Wilmot, Carly, Avis, Jacqueline, Hunyh, Truc, Daguia, Catherine, Schmedt, Christian, Noebels, Jeffrey, Jegla, Timothy
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928878/
https://www.ncbi.nlm.nih.gov/pubmed/20676103
http://dx.doi.org/10.1038/nn.2610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928878/
https://www.ncbi.nlm.nih.gov/pubmed/20676103
http://dx.doi.org/10.1038/nn.2610

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