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An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing

BACKGROUND: Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers: cyclic adenosine monophosphate (cAMP) and cyclic guanine monophosphate (cGMP). The cAMP-specific PDE family 4 (PDE4) is widely expressed in vertebrates. Each of the four PDE4 gene isoforms (PDE4 A-...

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Detalles Bibliográficos
Autores principales: Johnson, Keven R, Nicodemus-Johnson, Jessie, Danziger, Robert S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929239/
https://www.ncbi.nlm.nih.gov/pubmed/20701803
http://dx.doi.org/10.1186/1471-2148-10-247