Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

Manipulation of pathway regulation is an efficient strategy to increase specific secondary metabolite production. Here we successfully improved production of both the enediyne antitumor antibiotic C-1027 and a heptaebe, an early metabolite of the C-1027 pathway, by manipulating the three regulatory...

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Detalles Bibliográficos
Autores principales: Chen, Yihua, Yin, Min, Horsman, Geoff P., Huang, Shengxiong, Shen, Ben
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929275/
https://www.ncbi.nlm.nih.gov/pubmed/20551990
http://dx.doi.org/10.1038/ja.2010.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929275/
https://www.ncbi.nlm.nih.gov/pubmed/20551990
http://dx.doi.org/10.1038/ja.2010.55

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