A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth

Screening a phage-display single-chain antibody library for binding to the breast cancer cell line PM-1 an antibody, scFv173, recognising activated leukocyte cell adhesion molecule (ALCAM, CD166) was isolated and its binding profile was characterized. Positive ALCAM immunohistochemical staining of f...

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Detalles Bibliográficos
Autores principales: Wiiger, Merete Thune, Gehrken, Hege B., Fodstad, Øystein, Mælandsmo, Gunhild M., Andersson, Yvonne
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929338/
https://www.ncbi.nlm.nih.gov/pubmed/20635083
http://dx.doi.org/10.1007/s00262-010-0892-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929338/
https://www.ncbi.nlm.nih.gov/pubmed/20635083
http://dx.doi.org/10.1007/s00262-010-0892-3

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