Cheminformatics-Based Drug Design Approach for Identification of Inhibitors Targeting the Characteristic Residues of MMP-13 Hemopexin Domain

BACKGROUND: MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the protease has been intensively studied as a target for the inhibition of progress...

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Detalles Bibliográficos
Autores principales: Kothapalli, Roopa, Khan, Asif M., Basappa, Gopalsamy, Anupriya, Chong, Yap Seng, Annamalai, Loganath
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930869/
https://www.ncbi.nlm.nih.gov/pubmed/20824169
http://dx.doi.org/10.1371/journal.pone.0012494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930869/
https://www.ncbi.nlm.nih.gov/pubmed/20824169
http://dx.doi.org/10.1371/journal.pone.0012494

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