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A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels
The two human CLC Cl(−) channels, ClC-Ka and ClC-Kb, are almost exclusively expressed in kidney and inner ear epithelia. Mutations in the genes coding for ClC-Kb and barttin, an essential CLC-K channel β subunit, lead to Bartter syndrome. We performed a biophysical analysis of the modulatory effect...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931146/ https://www.ncbi.nlm.nih.gov/pubmed/20805576 http://dx.doi.org/10.1085/jgp.201010455 |