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Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node
The sympathetic nervous system increases heart rate by activating β adrenergic receptors and increasing cAMP levels in myocytes in the sinoatrial node. The molecular basis for this response is not well understood; however, the cardiac funny current (I(f)) is thought to be among the end effectors for...
Autores principales: | Liao, Zhandi, Lockhead, Dean, Larson, Eric D., Proenza, Catherine |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931151/ https://www.ncbi.nlm.nih.gov/pubmed/20713547 http://dx.doi.org/10.1085/jgp.201010488 |
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