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Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints
Treatment with anti-CD3 is a promising therapeutic approach for autoimmune diabetes, but its mechanism of action remains unclear. Foxp3(+) regulatory T (T reg) cells may be involved, but the evidence has been conflicting. We investigated this issue in mice derived from the NOD model, which were engi...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931163/ https://www.ncbi.nlm.nih.gov/pubmed/20679403 http://dx.doi.org/10.1084/jem.20100205 |