DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas

Aberrant DNA methylation commonly occurs in cancer cells where it has been implicated in the epigenetic silencing of tumor suppressor genes. Additional roles for DNA methylation, such as transcriptional activation, have been predicted but have yet to be clearly demonstrated. The BCL6 oncogene is imp...

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Detalles Bibliográficos
Autores principales: Lai, Anne Y., Fatemi, Mehrnaz, Dhasarathy, Archana, Malone, Christine, Sobol, Steve E., Geigerman, Cissy, Jaye, David L., Mav, Deepak, Shah, Ruchir, Li, Leping, Wade, Paul A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931164/
https://www.ncbi.nlm.nih.gov/pubmed/20733034
http://dx.doi.org/10.1084/jem.20100204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931164/
https://www.ncbi.nlm.nih.gov/pubmed/20733034
http://dx.doi.org/10.1084/jem.20100204

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