Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

Aβ peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein. Glycogen synthase kinase-3 (GSK-3) is increasingly implicated as playing a pivotal role in this amylo...

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Detalles Bibliográficos
Autores principales: Sofola, Oyinkan, Kerr, Fiona, Rogers, Iain, Killick, Richard, Augustin, Hrvoje, Gandy, Carina, Allen, Marcus J., Hardy, John, Lovestone, Simon, Partridge, Linda
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932684/
https://www.ncbi.nlm.nih.gov/pubmed/20824130
http://dx.doi.org/10.1371/journal.pgen.1001087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932684/
https://www.ncbi.nlm.nih.gov/pubmed/20824130
http://dx.doi.org/10.1371/journal.pgen.1001087

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