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Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†
[Image: see text] We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the neuraminidase (NA), which confers cross-resistance to all NA inhibitors. We analyzed enzyme properties of the D197 and E197 NAs and compared these to a D197N NA, known to arise after oseltamivir...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932999/ https://www.ncbi.nlm.nih.gov/pubmed/20695427 http://dx.doi.org/10.1021/jm100621s |