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Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under Flow Conditions

BACKGROUND: Pregnancy-associated malaria (PAM) is a serious consequence of the adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum-infected erythrocytes (PE) expressing the large cysteine-rich multi-domain protein var2CSA. Women become resistant to PAM, and develo...

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Detalles Bibliográficos
Autores principales: Fernandez, Pablo, Petres, Stéphane, Mécheri, Salaheddine, Gysin, Jürg, Scherf, Artur
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933227/
https://www.ncbi.nlm.nih.gov/pubmed/20838433
http://dx.doi.org/10.1371/journal.pone.0012558