An Overlapping Kinase and Phosphatase Docking Site Regulates Activity of the Retinoblastoma Protein

The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein (Rb) are modulated by a balance of kinase and phosphatase activities. Here we characterize the association of Rb with the catalytic subunit of protein phosphatase 1 (PP1c). A crystal structure identif...

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Detalles Bibliográficos
Autores principales: Hirschi, Alexander, Cecchini, Matthew, Steinhardt, Rachel C., Dick, Frederick A., Rubin, Seth M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933323/
https://www.ncbi.nlm.nih.gov/pubmed/20694007
http://dx.doi.org/10.1038/nsmb.1868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933323/
https://www.ncbi.nlm.nih.gov/pubmed/20694007
http://dx.doi.org/10.1038/nsmb.1868

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