Rb regulates fate choice and lineage commitment in vivo

Mutation of the RB-1 tumour suppressor occurs in one third of all human tumours and is particularly associated with retinoblastoma and osteosarcoma1. Numerous functions have been ascribed to the product of the human RB-1 gene, pRB. The best known is pRB’s ability to promote cell cycle exit through i...

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Detalles Bibliográficos
Autores principales: Calo, Eliezer, Quintero-Estades, Jose A., Danielian, Paul S., Nedelcu, Simona, Berman, Seth D., Lees, Jacqueline A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933655/
https://www.ncbi.nlm.nih.gov/pubmed/20686481
http://dx.doi.org/10.1038/nature09264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933655/
https://www.ncbi.nlm.nih.gov/pubmed/20686481
http://dx.doi.org/10.1038/nature09264

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