Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3

BACKGROUND: The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although 3...

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Detalles Bibliográficos
Autores principales: Salaemae, Wanisa, Junaid, Muhammad, Angsuthanasombat, Chanan, Katzenmeier, Gerd
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933675/
https://www.ncbi.nlm.nih.gov/pubmed/20735839
http://dx.doi.org/10.1186/1423-0127-17-68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933675/
https://www.ncbi.nlm.nih.gov/pubmed/20735839
http://dx.doi.org/10.1186/1423-0127-17-68

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