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Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3
BACKGROUND: The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although 3...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933675/ https://www.ncbi.nlm.nih.gov/pubmed/20735839 http://dx.doi.org/10.1186/1423-0127-17-68 |