BACE1(-/- )mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

BACKGROUND: BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. Examination of BACE1(-/- )mice can provide insi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hitt, Brian D, Jaramillo, Thomas C, Chetkovich, Dane M, Vassar, Robert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933677/
https://www.ncbi.nlm.nih.gov/pubmed/20731874
http://dx.doi.org/10.1186/1750-1326-5-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933677/
https://www.ncbi.nlm.nih.gov/pubmed/20731874
http://dx.doi.org/10.1186/1750-1326-5-31

Ejemplares similares