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BACE1(-/- )mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
BACKGROUND: BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. Examination of BACE1(-/- )mice can provide insi...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933677/ https://www.ncbi.nlm.nih.gov/pubmed/20731874 http://dx.doi.org/10.1186/1750-1326-5-31 |