Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members. WS cells exhibit genomic instability and altered proliferation, and in vitro studies suggest that WRN has a role in sup...

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Detalles Bibliográficos
Autores principales: Brown, Adam D., Claybon, Alison B., Bishop, Alexander J. R.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933912/
https://www.ncbi.nlm.nih.gov/pubmed/20847942
http://dx.doi.org/10.4061/2010/356917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933912/
https://www.ncbi.nlm.nih.gov/pubmed/20847942
http://dx.doi.org/10.4061/2010/356917

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