M Protein and Hyaluronic Acid Capsule Are Essential for In Vivo Selection of covRS Mutations Characteristic of Invasive Serotype M1T1 Group A Streptococcus

The initiation of hyperinvasive disease in group A Streptococcus (GAS) serotype M1T1 occurs by mutation within the covRS two-component regulon (named covRS for control of virulence regulatory sensor kinase), which promotes resistance to neutrophil-mediated killing through the upregulation of bacteri...

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Detalles Bibliográficos
Autores principales: Cole, Jason N., Pence, Morgan A., von Köckritz-Blickwede, Maren, Hollands, Andrew, Gallo, Richard L., Walker, Mark J., Nizet, Victor
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934611/
https://www.ncbi.nlm.nih.gov/pubmed/20827373
http://dx.doi.org/10.1128/mBio.00191-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934611/
https://www.ncbi.nlm.nih.gov/pubmed/20827373
http://dx.doi.org/10.1128/mBio.00191-10

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