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Structural Basis for the Transcriptional Regulation of Membrane Lipid Homeostasis

DesT is a transcriptional repressor that regulates the genes which control the unsaturated:saturated fatty acid ratio available for membrane lipid synthesis. DesT bound to unsaturated acyl-CoA has a high affinity for its cognate palindromic DNA-binding site, whereas DesT bound to saturated acyl-CoA...

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Detalles Bibliográficos
Autores principales: Miller, Darcie J., Zhang, Yong-Mei, Subramanian, Chitra, Rock, Charles O., White, Stephen W.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935088/
https://www.ncbi.nlm.nih.gov/pubmed/20639888
http://dx.doi.org/10.1038/nsmb.1847