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Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction
The ERK5 cascade is a MAPK pathway that transmits both mitogenic and stress signals, yet its mechanism of activation is not fully understood. Using intracellular calcium modifiers, we found that ERK5 activation by EGF is inhibited both by the depletion and elevation of intracellular calcium levels....
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935384/ https://www.ncbi.nlm.nih.gov/pubmed/20830310 http://dx.doi.org/10.1371/journal.pone.0012627 |