A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

Thrombopoietin (TPO) via signaling through its cognate receptor MPL is a key cytokine involved in the regulation of megakaryocyte differentiation leading to platelet production. Mature megakaryocytes are polyploid cells that have arrested DNA replication and cellular proliferation but continue susta...

Descripción completa

Detalles Bibliográficos
Autores principales: Besancenot, Rodolphe, Chaligné, Ronan, Tonetti, Carole, Pasquier, Florence, Marty, Caroline, Lécluse, Yann, Vainchenker, William, Constantinescu, Stefan N., Giraudier, Stéphane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935456/
https://www.ncbi.nlm.nih.gov/pubmed/20838657
http://dx.doi.org/10.1371/journal.pbio.1000476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935456/
https://www.ncbi.nlm.nih.gov/pubmed/20838657
http://dx.doi.org/10.1371/journal.pbio.1000476

Ejemplares similares