Complete Biallelic Insulation at the H19/Igf2 Imprinting Control Region Position Results in Fetal Growth Retardation and Perinatal Lethality

BACKGROUND: The H19/Igf2 imprinting control region (ICR) functions as an insulator exclusively in the unmethylated maternal allele, where enhancer-blocking by CTCF protein prevents the interaction between the Igf2 promoter and the distant enhancers. DNA methylation inhibits CTCF binding in the pater...

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Detalles Bibliográficos
Autores principales: Lee, Dong-Hoon, Singh, Purnima, Tsark, Walter M. K., Szabó, Piroska E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935888/
https://www.ncbi.nlm.nih.gov/pubmed/20838620
http://dx.doi.org/10.1371/journal.pone.0012630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935888/
https://www.ncbi.nlm.nih.gov/pubmed/20838620
http://dx.doi.org/10.1371/journal.pone.0012630

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