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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear. We generated isogenic cell lines stably expressing AMPK complexes containing AMP-sensitive (wild-type, WT) or AMP-insensitive (R531G) γ2 variants. Mitochondrial poisons such as oligomycin and dinitrophenol only...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935965/ https://www.ncbi.nlm.nih.gov/pubmed/20519126 http://dx.doi.org/10.1016/j.cmet.2010.04.001 |