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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear. We generated isogenic cell lines stably expressing AMPK complexes containing AMP-sensitive (wild-type, WT) or AMP-insensitive (R531G) γ2 variants. Mitochondrial poisons such as oligomycin and dinitrophenol only...

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Detalles Bibliográficos
Autores principales:	Hawley, Simon A., Ross, Fiona A., Chevtzoff, Cyrille, Green, Kevin A., Evans, Ashleigh, Fogarty, Sarah, Towler, Mhairi C., Brown, Laura J., Ogunbayo, Oluseye A., Evans, A. Mark, Hardie, D. Grahame
Formato:	Texto
Lenguaje:	English
Publicado:	Cell Press 2010
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935965/ https://www.ncbi.nlm.nih.gov/pubmed/20519126 http://dx.doi.org/10.1016/j.cmet.2010.04.001

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