Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Seq...

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Autores principales: Wadelin, Frances, Fulton, Joel, McEwan, Paul A, Spriggs, Keith A, Emsley, Jonas, Heery, David M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936344/
https://www.ncbi.nlm.nih.gov/pubmed/20799951
http://dx.doi.org/10.1186/1476-4598-9-226
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author Wadelin, Frances
Fulton, Joel
McEwan, Paul A
Spriggs, Keith A
Emsley, Jonas
Heery, David M
author_facet Wadelin, Frances
Fulton, Joel
McEwan, Paul A
Spriggs, Keith A
Emsley, Jonas
Heery, David M
author_sort Wadelin, Frances
collection PubMed
description PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
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spelling pubmed-29363442010-09-10 Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia Wadelin, Frances Fulton, Joel McEwan, Paul A Spriggs, Keith A Emsley, Jonas Heery, David M Mol Cancer Review PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia. BioMed Central 2010-08-27 /pmc/articles/PMC2936344/ /pubmed/20799951 http://dx.doi.org/10.1186/1476-4598-9-226 Text en Copyright ©2010 Wadelin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wadelin, Frances
Fulton, Joel
McEwan, Paul A
Spriggs, Keith A
Emsley, Jonas
Heery, David M
Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title_full Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title_fullStr Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title_full_unstemmed Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title_short Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
title_sort leucine-rich repeat protein prame: expression, potential functions and clinical implications for leukaemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936344/
https://www.ncbi.nlm.nih.gov/pubmed/20799951
http://dx.doi.org/10.1186/1476-4598-9-226
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