Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins

BACKGROUND: Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of...

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Detalles Bibliográficos
Autores principales: Lunde, Elin, Løset, Geir Åge, Bogen, Bjarne, Sandlie, Inger
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936418/
https://www.ncbi.nlm.nih.gov/pubmed/20735812
http://dx.doi.org/10.1186/1472-6750-10-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936418/
https://www.ncbi.nlm.nih.gov/pubmed/20735812
http://dx.doi.org/10.1186/1472-6750-10-61

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